重組人SAA 蛋白質(zhì)純化方法

SAA是一種急性相蛋白并與血漿高密度脂蛋白(HDL)結(jié)合?，F(xiàn)在，臨床研究把目光集中在炎性疾病急性反應(yīng)期間的SAA類型。與已被充分證實(shí)的急性相蛋白-CRP比較，SAA被用來(lái)檢驗(yàn)其在急性炎性疾病的診斷中是否有任何優(yōu)點(diǎn)仍有待確定。

與CRP相仿，用以評(píng)估急性相反應(yīng)進(jìn)程。SAA是個(gè)靈敏的參數(shù)，它在炎性反應(yīng)大約8h后開(kāi)始升高，且超過(guò)參考范圍上*早于CRP，然而CRP在正常人中的中位數(shù)值與參考范圍上限的差距，大約有10倍。在SAA中僅有5倍。輕微感染，例如，許多病毒感染，SAA升高要比CRP更為常見(jiàn)。在感染性疾病中，SAA的上升要高于CRP，因此SAA測(cè)定，尤其對(duì)“正常”與微小急性相反應(yīng)可提供更好的鑒別。通常約2/3感冒患者SAA升高，但少于1/2的患者相同表現(xiàn)CRP升高。在病毒感染病例中，SAA和CRP濃度升高見(jiàn)于腺病毒感染者。

分 子 量：14kDa
性    狀：Liquid
濃    度：0.8mg/ml
產(chǎn)品來(lái)源：基因工程表達(dá)
分    類：重組蛋白
純化方法：親和層析
產(chǎn)品應(yīng)用：Immunology research 
保存條件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹：Serum amyloid A1 (SAA1) is a protein that in humans is encoded by the SAA1 gene. SAA1 is a major acute-phase protein mainly produced by hepatocytes in response to infection, tissue injury and malignancy. When released into blood circulation, SAA1 is present as an apolipoprotein associated with high-density lipoprotein (HDL). SAA1 is a major precursor of amyloid A (AA), the deposit of which leads to inflammatory amyloidosis.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.